DNA in nanochannels

We study how the orientational correlations of DNA confined to nanochannels depend on the
channel diameter D by means of Monte Carlo simulations and a mean-field theory.



This theory describes DNA conformations in the experimentally relevant regime where the Flory-de Gennes theory does not apply. We show how local correlations determine the dependence of the end-to-end distance of the DNA molecule upon D. Tapered nanochannels provide the necessary resolution in D to study experimentally how the extension of con ned DNA molecules depends upon D. Our experimental and theoretical results are in qualitative agreement.

Orientational correlations in confined DNA
E. Werner, F. Persson, F. Westerlund, J. Tegenfeldt & B. Mehlig, Phys. Rev. E in press (2012)